The innovative activity of the state is a key factor in ensuring sustainable economic growth and global competitiveness. In the context of sanctions pressure and the need to achieve technological sovereignty, the task of identifying systemic trends that determine the opportunities and results of scientific and technological development is becoming relevant. The purpose of the article is to identify and substantiate the key areas of scientific and technical progress that form the architecture of management solutions for technological modernization. The research methodology includes analysis of the conceptual and categorical framework and strategic objectives of scientific and technological development, a comprehensive assessment of the dynamics of indicators such as organizational innovation activity, R&D costs and patent activity and trend forecasting. The research tools are based on the application of system analysis elements, which make it possible to identify a set of conditions and actions that determine scientific and technological development. As a result, the authors developed an interconnected set of conditions and actions that ensure a systematic approach to enhancing scientific and technological development. The key positions of the areas requiring increased attention are: setting strategic objectives for the priorities of scientific and technological development, analyzing its current state, as well as forecasting indicators. The identification of specific activities ranked by priority will allow correlating the available opportunities for achieving results. The practical relevance of the research consists in substantiating the priority directions of scientific and technological development, synchronized with national projects and strategic documents. The developed methodological framework makes it possible to form targeted public policy measures aimed at overcoming key barriers and realizing Russia's competitive advantages in the scientific and technological sphere.